Endocrine Abstracts

Abstract unavailable....

One of the fundamental challenges facing current biology concerns the molecular basis for stem cell formation and behaviour. Haematopoiesis is the best characterised adult stem cell system and continues to provide paradigms of broad biological relevance. The stem cell leukaemia (SCL) gene encodes a transcription factor that is essential for the normal development of haematopoietic stem cells (HSC) and all haematopoietic lineages. Appropriate transcriptional regulation is criti...

Aim: Promoting cohesion, community and knowledge of diabetes through the co-production of a video exploring the social and clinical impact of attending a residential activity camp for children and families living with type 1 diabetesMethod: From our knowledge of attending previous diabetes camps, the video will begin by highlighting the background and motivation behind the study, emphasising the limited understanding of ...

Aim: Camps offer valuable opportunities for creating a supportive environment of like-minded people with similar experiences of living with diabetes, thereby promoting self-efficacy, wellbeing and a healthy life style. In the midst of a post-Covid cost of living crisis, finance was identified as a major obstacle for families wishing to attend residential diabetes camps. A sustainable strategy, supported by co-production with young people, was needed to facilit...

Cranial diabetes insipidus (CDI) is commonly idiopathic but can also be due to tumours of the pituitary & hypothalamus or surgery to remove these tumours. It can also occur due to infiltrative processes including metastatic malignancy. Pituitary metastases are not a common clinical entity although it can be a common finding in autopsy in advanced cancer when the pituitary & the sella have been evaluated. In this abstract, I will discuss two cases of CDI as a presentati...

Optimal in-patient glycaemic control improves morbidity and mortality in in-patients with diabetes1. The National Inpatient Diabetes Audit (NaDIA) is an annual snapshot audit of diabetes inpatient care in England and in Wales. We performed a similar audit in Our Lady of Lourdes Hospital, Drogheda (OLOLHD, 363 in-patient beds) on 26/01/2022 and 08/10/2020. Data from all adult in-patients with diabetes were gathered using a standard proforma. Data from the OLOLHD 2022...

Aim to elucidate the factors influencing length of stay (LOS) in patients with hyponatraemia admitted to an acute medical unit (AMU).Methodology: a prospective study of patients admitted to AMU at West Middlesex University Hospital from November 2009 to June 2011. A proforma was completed for each patient by the registrar on his duty days.Results: 70 patients were identified with a mean age of 69.2 years. 41 (59%) were female. 20 (...

ObjectiveTo assess the results of bilateral adrenalectomy and further assess the relevance of Nelson's syndrome as a complication of bilateral adrenalectomy.Patients33 patients treated by bilateral adrenalectomy at the Hammersmith Hospital were identified (earliest operation performed in 1958). Although all bilateral adrenalectomies in recent years were included, it was not possible to confirm that all bilate...

Somatostatin (sst) acts via five G-protein-coupled receptors (sstr) that effect angiogenesis, cell proliferation and apoptosis. We have reported the expression of these receptors in normal endometrium and in this study we have extended those observations to the expression of sstr subtypes 1, 2, 3, and 5 within hyperplastic and neoplastic endometrium using immunohistochemistry. METHOD The avidin-biotin-peroxidase method was used to immunostain formalin-fixed, paraffin-embedded ...

Background: Pancreatic mixed acinar-neuroendocrine carcinomas are a rare distinctive entity with histologic and immunohistochemical features of pancreatic acinar cell carcinoma and pancreatic neuroendocrine tumor and pose diagnostic challenges. Very few cases have been described in the literature. Genomic information about these tumors remains unknown. We identified two cases of mixed acinar- neuroendocrine carcinoma from our database since January 2020 who had full genomic in...